Is there a Premotor Phase of Essential Tremor?

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Is there a Premotor Phase of Essential Tremor?

BACKGROUND Essential tremor (ET) is the most common tremor disorder. In addition to its hallmark feature, kinetic tremor of the upper limbs, patients may have a number of non-motor symptoms and signs (NMS). Several lines of evidence suggest that ET is a neurodegenerative disorder and certain NMS may antedate the onset of tremor. This article comprehensively reviews the evidence for the existenc...

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What is essential tremor?

Classic essential tremor is a clinical syndrome of action tremor in the upper limbs (at least 95 % of patients) and less commonly the head, face/jaw, voice, tongue, trunk, and lower limbs, in the absence of other neurologic signs. However, the longstanding notion that essential tremor is a monosymptomatic tremor disorder is being challenged by a growing literature describing associated disturba...

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Thalamic physiology of intentional essential tremor is more like cerebellar tremor than postural essential tremor

The neuronal physiological correlates of clinical heterogeneity in human essential tremor are unknown. We now test the hypothesis that thalamic neuronal and EMG activities during intention essential tremor are similar to those of the intention tremor which is characteristic of cerebellar lesions. Thalamic neuronal firing was studied in a cerebellar relay nucleus (ventral intermediate, Vim) and ...

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How Common Is Essential Tremor?

lent than Parkinson’s disease in Arabic villagers in Israel (ET prevalence = 0.78% vs. PD prevalence = 1.44%) [12] ; however, those results are atypical. The incidence of ET has been examined in only 2 studies [13, 14] . The incidence rate reported for ET, based on a populationbased study (the NEDICES study) [13] , was substantially higher (6.3 per 1,000 person-years) than that reported in the ...

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How common is essential tremor?

lent than Parkinson’s disease in Arabic villagers in Israel (ET prevalence = 0.78% vs. PD prevalence = 1.44%) [12] ; however, those results are atypical. The incidence of ET has been examined in only 2 studies [13, 14] . The incidence rate reported for ET, based on a populationbased study (the NEDICES study) [13] , was substantially higher (6.3 per 1,000 person-years) than that reported in the ...

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ژورنال

عنوان ژورنال: Tremor and Other Hyperkinetic Movements

سال: 2017

ISSN: 2160-8288

DOI: 10.5334/tohm.382